Many such problems involve estimation of unknown constants or even unknown functions. Professor Cox has done fundamental research in the use of spline functions for such applications and extensive work in developing methodologies and practical computational approaches. He has collaborated with investigators from such disciplines as electrical engineering, neurophysiology, oncology, and economics but currently is most active in applications in nuclear fusion research. He expects that there will be applications for such methodologies in materials science and atmospheric science as well. Professor Cox has also done theoretical work in nonparametric function estimation, statistical approximation theory, and Bayesian methods.