Statistical Genetics and Bioinformatics
Professor Guerra is generally interested in biological problems with an emphasis in biomedical research. Longtime collaboration with investigators from University of Texas Southwestern Medical Center have centered on statistical genetics whereby statistical methods are developed to analyze genetic data, especially with a view toward genotype-phenotype relationships. Such efforts include study design for genetic epidemiologic studies, linkage and association, and statistical models to account for both genetic and environmental factors influencing heritable traits. Current interests include meta-analysis for genetic linkage studies, case-control studies using haplotype blocks, and identification of multiple genetic markers influencing a single trait. More recently, I have been learning about bioinformatics via microarray studies and biological pathways. Projects in these areas are motivated by various system biology efforts with University of Texas Medical Branch (UTMB,Galveston), Baylor College of Medicine, and MD Anderson Cancer Center.